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While on a school field trip, nerdy high school student Peter Parker is bitten by a genetically modified spider and granted spider-like abilities. At first using these new skills to impress his crush, Mary Jane Watson, Peter's new life is devastated by the murder of his beloved uncle, Ben Parker. Determined to prevent such tragedies from ever occurring again, Peter becomes the new crime fighting superhero Spider-Man. Peter must learn to juggle his home life with his aunt May Parker, his love life with MJ, his friendship with Harry Osborn, his job at the Daily Bugle under the employ of J. Jonah Jameson, and his new superhero life, while also battling a number of supervillains, such as The Green Goblin, Doctor Octopus, The Sandman and Venom.